{"query": "Chronic disease as nested control-system failure — a hardene", "count": 20, "results": [{"id": "card_theory_systems_engineering", "title": "Systems engineering (requirements, interfaces, and emergent failure)", "shelf": "theories", "surface": "secular", "snippet": "Systems engineering (requirements, interfaces, and emergent failure) — an engine domain that can touch it: operations_research. Calibration: map-only — a discipline of practice; reliability and margin", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_n_e41105aaa59f", "title": "Chronic disease as nested control-system failure — a hardened, falsifiable framework", "shelf": "science", "surface": "secular", "snippet": "Matt's public-domain framework: chronic disease is not one broken part but a failure somewhere in a\nNESTED CONTROL SYSTEM — five layers, each regulating the one below: (1) Cellular stress response →\n(", "authority_tier": "engine_derived", "source": "Concordance assay — 2026-07-10", "generated": false}, {"id": "card_theory_requisite_variety", "title": "Ashby's law of requisite variety (the humility theorem)", "shelf": "theories", "surface": "secular", "snippet": "Ashby's law of requisite variety (the humility theorem) — an engine domain that can touch it: operations_research. Calibration: map-only — a structural bound, stated in variety counts rather than comp", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_g_del_s_incompleteness_theorems", "title": "Gödel's incompleteness theorems", "shelf": "theories", "surface": "secular", "snippet": "Gödel's incompleteness theorems — an engine domain that can touch it: formal_logic. Calibration: map-only — a meta-theorem about systems, not a sealable computation. FIRST (1931): any consistent forma", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_percolation", "title": "Percolation & critical thresholds", "shelf": "theories", "surface": "secular", "snippet": "Percolation & critical thresholds — an engine domain that can touch it: physics. Calibration: seals — thresholds and cluster statistics compute. Fill a lattice at random with probability p. Below a cr", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_germ_theory_of_disease", "title": "Germ theory of disease", "shelf": "theories", "surface": "secular", "snippet": "Germ theory of disease — an engine domain that can touch it: medicine. Calibration: map-only — a foundational empirical claim. Specific microorganisms cause specific diseases. Established by Pasteur a", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_reliability_tolerance_stack_up", "title": "Reliability & tolerance stack-up (RSS)", "shelf": "theories", "surface": "secular", "snippet": "Reliability & tolerance stack-up (RSS) — an engine domain that can touch it: manufacturing. Calibration: seals — reliability products and RSS tolerances compute. Series reliability MULTIPLIES: a chain", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_dynamical_systems___deterministic_chaos", "title": "Dynamical systems & deterministic chaos", "shelf": "theories", "surface": "secular", "snippet": "Dynamical systems & deterministic chaos — an engine domain that can touch it: mathematics. Calibration: map-only — sensitivity is qualitative; specific trajectories compute. Deterministic rules whose ", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_src_word_chronic_kidney_failure", "title": "chronic kidney failure", "shelf": "dictionary", "surface": "secular", "snippet": "chronic kidney failure: (noun) renal failure that can result from a variety of systemic disorders — syn: chronic renal failure", "authority_tier": "reference", "source": "WordNet 3.0, Princeton University (WordNet License)", "generated": false}, {"id": "card_src_word_chronic_renal_failure", "title": "chronic renal failure", "shelf": "dictionary", "surface": "secular", "snippet": "chronic renal failure: (noun) renal failure that can result from a variety of systemic disorders — syn: chronic kidney failure", "authority_tier": "reference", "source": "WordNet 3.0, Princeton University (WordNet License)", "generated": false}, {"id": "card_theory_photographic_exposure_theory", "title": "Photographic exposure theory (exposure value, reciprocity)", "shelf": "theories", "surface": "secular", "snippet": "Photographic exposure theory (exposure value, reciprocity) — an engine domain that can touch it: photography. Calibration: seals — exposure values and equivalent settings compute. Three controls set h", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_theory_homeostasis_physiological_regulation", "title": "Homeostasis & physiological regulation", "shelf": "theories", "surface": "secular", "snippet": "Homeostasis & physiological regulation — an engine domain that can touch it: medicine. Calibration: partial — specific indices compute; the framework is empirical. A body holds its internal conditions", "authority_tier": "reference", "source": "The Theory Assay — calibrated, not judged (docs/THEORY_CATALOG.md)", "generated": false}, {"id": "card_ncs_l4_autonomic_actuators", "title": "Autonomic Nervous System — the actuators", "shelf": "regulation", "surface": "secular", "snippet": "Level 4 of the Nested Control-Systems stack. The physical state actuators: sympathetic/parasympathetic branches are the downstream effectors of hierarchical command, not the primary drivers of dysregu", "authority_tier": "reference", "source": "Autonomic physiology (sympathetic/parasympathetic effectors); downstream of L1–L3 control.", "generated": false}, {"id": "card_src_book_65808", "title": "Pecan Diseases and Pests and Their Control — David W. Rosburg", "shelf": "gutenberg", "surface": "secular", "snippet": "Pecan Diseases and Pests and Their Control, by David W. Rosburg. Subjects: Pecan -- Diseases and pests; Pecan -- Diseases and pests -- Control. Read the full text (public domain): https://www.gutenber", "authority_tier": "reference", "source": "Project Gutenberg (public domain)", "generated": false}, {"id": "card_works_nested_control", "title": "The nested control-systems rule: meet a failure at its own layer", "shelf": "the-works", "surface": "secular", "snippet": "From Matt's Nested Control-Systems Framework: regulation is a stack of layers, and the layers do not compete — they nest. Two validity rules follow, and the engine checks them. First, a failure at a h", "authority_tier": "verified", "source": "The Works — worked & sealed", "generated": false}, {"id": "card_src_book_59663", "title": "Notes on Diseases of Swine, Sheep, Poultry and the Dog Cause, Symptoms and Treatments — Charles James Korinek", "shelf": "gutenberg", "surface": "secular", "snippet": "Notes on Diseases of Swine, Sheep, Poultry and the Dog Cause, Symptoms and Treatments, by Charles James Korinek. Subjects: Dogs -- Diseases; Poultry -- Diseases; Swine -- Diseases; Sheep -- Diseases. ", "authority_tier": "reference", "source": "Project Gutenberg (public domain)", "generated": false}, {"id": "card_src_word_chronic_obstructive_pulmonary_disease", "title": "chronic obstructive pulmonary disease", "shelf": "dictionary", "surface": "secular", "snippet": "chronic obstructive pulmonary disease: (noun) a nonreversible lung disease that is a combination of emphysema and chronic bronchitis; usually patients have been heavy cigarette smokers", "authority_tier": "reference", "source": "WordNet 3.0, Princeton University (WordNet License)", "generated": false}, {"id": "card_src_book_43780", "title": "The Lettsomian Lectures on Diseases and Disorders of the Heart and Arteries in Middle and Advanced Life [1900-1901] — J. Mitchell (John Mitchell) Bruce", "shelf": "gutenberg", "surface": "secular", "snippet": "The Lettsomian Lectures on Diseases and Disorders of the Heart and Arteries in Middle and Advanced Life [1900-1901], by J. Mitchell (John Mitchell) Bruce. Subjects: Heart -- Diseases; Arteries -- Dise", "authority_tier": "reference", "source": "Project Gutenberg (public domain)", "generated": false}, {"id": "card_v_5a5b7cd96aee", "title": "an L4 failure is met at L4 (≥ the failing layer), not by L1/L2 alone · a set-poi", "shelf": "biology", "surface": "secular", "snippet": "Verdict: HOLDS.\n• biology.failure_mode_taxonomy: no failure_mode declared — taxonomy check skipped; biology.control_layer_match: highest intervention layer (L4) >= failure layer (L4)\n• biology.failure", "authority_tier": "engine", "source": "Verified by the engine — biology", "generated": false}, {"id": "card_ncs_l1_predictive_processing", "title": "Predictive Processing / Active Inference", "shelf": "regulation", "surface": "secular", "snippet": "Level 1 of the Nested Control-Systems stack. The computational frame: the brain minimizes prediction error and selects policies; autonomic shifts are action policies, meltdowns a cascading precision-a", "authority_tier": "reference", "source": "Friston (2005), Phil. Trans. R. Soc. B 360:815; Lawson, Rees & Friston (2014), Front. Hum. Neurosci. 8:302 (aberrant precision account of autism).", "generated": false}]}