{"id": "card_n_77d37f00f1dd", "kind": "note", "title": "Base pairing and the central dogma", "body": "The information flows DNA -> RNA -> protein (Crick's central dogma), and it is held by\ncomplementary pairs: A binds T with two hydrogen bonds, G binds C with three. Chargaff's rule\n(that A=T and G=C in any genome's counts) was the clue Watson and Crick needed. The engine\nverifies complements in-domain (https://narrowhighway.com/s/81e65a70a2e8e96d2e46f9d45523790c95ed9fe05ea8f89284b0d35845d11b27 ). That one extra bond on G-C is why GC-rich DNA melts\nat a higher temperature — an empirical, measured property that thermophiles exploit. The double\nhelix is a two-strand error-correcting code: each strand is the other's backup.", "source": {"label": "Concordance assay — 2026-07-09", "url": "https://narrowhighway.com/s/f8a7bbf4b8b3da9cadedda1d5228d6aa1683c60a1d79c3655c4eae419119276c", "ref": "genetics", "authority_tier": "engine_derived"}, "shelf": "science", "box": "genetics", "bands": ["base pairing", "chargaff", "central dogma", "watson crick", "hydrogen bonds", "gc content", "double helix", "crick"], "connections": [], "author": "engine", "created_at": "2026-07-10T01:49:27.180353+00:00", "updated_at": "2026-07-10T01:49:27.180353+00:00", "visibility": "public", "lifecycle_stage": "public", "volatility": "permanent", "surface": "secular", "metrics": {"paperclips_count": 0, "helpful_count": 0, "not_helpful_count": 0, "cite_count": 0, "walks_through_count": 0, "flagged_count": 0}, "source_hash": "99beb51ad8adbef02ced3b98edd430777eefdb1cdb8100c617474c409c3b956a"}